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Objective To explore the role of cerebral infarction regions in predicting the progressive cerebral infarction (PCI). Methods One hundred and sixteen patients with cerebral infarction from Oct 2016 to Oct 2017 were selected. Patients were classified into cortical, basal gangliaon, coronaradiata and posterior circulation infarction according different regions. The patients were divided into non-PCI group and PCI group according to their clinical manifestations. The role of cerebral infarction regions in predicting the progressive cerebral infarction was conducted by unitary analysis and multivariate analysis. Results Eighty-five cases of non-PCI and 31 cases of PCI were included. The number of cases of cortical, basal gangliaon, coronaradiata and posterior circulation infarction were 55, 29, 21 and 10. Multivariate analysis showed that age (OR=1.257, 95％CI 1.117-2.426, P=0.031), history of diabetes (OR=1.342, 95％CI 1.121-2.162, P=0.022), systolic pressure (OR=1.264, 95％ CI 1.254- 2.209, P=0.033), location of infarct (OR=1.153, 95％ CI 1.064-1.528, P=0.041), baseline NIHHS score (OR=1.634, 95％ CI 1.248- 1.688, P=0.029) were independent risk factors affecting the occurrence of progressive cerebral infarction. The frequency of progression was significantly increased in cortical infarction , compared with that in other subtypes of cerebral infarction. The trend was still significant even after adjustment for age and systolic pressure. Conclusions The occurrence of progressive cerebral infarction is influenced by multiple factors, and the location of the infarct is one of its independent risk factors, especially for patients with cortical infarction.
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<p><b>OBJECTIVE</b>To evaluate the role of muscle fatigue in the pathogenesis of high prevalence of low back pain(LBP) in drivers who work at high altitude, in order to seek the effective measures for prevention and treatment of LBP.</p><p><b>METHOD</b>The spectral electromyographic(EMG) changes during isometric contraction of erector spinalis to fatigue in 26 drivers in the field were consecutively recorded after daily driving for 5 days. The relationship between the decline of median frequency and the development of the back extensor fatigue were analyzed.</p><p><b>RESULTS</b>The decline rates of EMG median frequency of the erector spinalis on 1-5 working day [(-0.258 +/- 0.087), (-0.248 +/- 0.070), (-0.256 +/- 0.097), (-0.267 +/- 0.093), (-0.274 +/- 0.081)%/s respectively] were significantly different from that of baseline measured before work [(-0.175 +/- 0.114)%/s, P < 0.05 or P < 0.01]. A positive correlation was also found between the decline rate and the working time(r = -0.809, P < 0.05).</p><p><b>CONCLUSION</b>The high prevalence of LBP in the drivers working at high altitude is due to acumulative fatigue of back extensor resulting from long-distance driving, lack of proper rest, decrease of muscle endurance and increase of liability to fatigue, consequently leading to the muscle dysfunction and finally LBP.</p>
Subject(s)
Humans , Altitude , Automobile Driving , Electromyography , Low Back Pain , Muscle Fatigue , Physiology , Occupational DiseasesABSTRACT
<p><b>OBJECTIVE</b>To investigate the epidemiological characteristics of lower back pain of truck drivers in plateau areas with an analysis of the causes and evaluated the effects of the protective measures.</p><p><b>METHODS</b>The self-reported lower back symptom was investigated by questionnaire in 1,132 male drivers in plateau areas. Vibration of the driver lumbar back was measured real time with or without wearing corset. Study the effect of the special corset for drivers and the massage on back by self-control design of big sample intervention experiments.</p><p><b>RESULTS</b>The prevalence of lower back pain of drivers in plateau areas was 86.1%. High level of its prevalence is due to many factors. Special corset for drivers and massage on back by themselves can reduce the degree of the pain.</p><p><b>CONCLUSION</b>Driving in plateau areas is a special occupational work with high level of prevalence of lower back pain which can be prevented.</p>
Subject(s)
Humans , Male , Automobile Driving , Low Back Pain , Epidemiology , Occupational Diseases , Prevalence , Surveys and QuestionnairesABSTRACT
AIM: To explore the effect of EBV infection on growth and apoptosis of nasopharyngeal carcinoma(NPC) cell line.METHODS: NPC cell line CNE1 was directly infected by Epstein Barr virus (EBV). The expression of EBV-latent membrane protein 1 (EBV-LMP1) and bcl-2 were detected by immunohistochemistry method (LSAB). The growth of NPC cells was identified by MTT method. Apoptotic carcinoma cells were detected by flow cytometry analysis and the terminal deoxynucletidyl transferase-medicated dUTP-biotin nick end labeling (TUNEL) methods. RESULTS: EBV-LMP1 was positive in CNE1 infected by EBV(E-CNE1). Compared with CEN1, the growth of E-CNE1 apparently increased ( P
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AIM:To investigate the effect of Epstain-Barr virus latent membrane protein 1 (EBV-LMP1) on proliferation and cell cycle of nasopharyngeal carcinoma (NPC) cells. METHODS:The expression of EBV-LMP1 was detected by immunohistochemical method (LSAB). Proliferation of NPC cells was identified by MTT method. Cell cycle percentage was detected by flow cytometry analysis. RESULTS: OD value of EBV-LMP1 expressive NPC cells L-CEN1 was much higher than that of both EBV-LMP1 negative NPC cells V-CEN1 and CNE1 ( P 0.05).CONCLUSION:The expression of EBV-LMP1 on NPC cell might cause some change of cell cycle and enhance cell proliferation.